|
KMID : 0043320070300050565
|
|
Archives of Pharmacal Research
2007 Volume.30 No. 5 p.565 ~ p.569
|
|
|
Cytotoxic Constituents from Angelicae Sinensis Radix
|
|
Chen Quan Cheng
Lee Jong-Pill
Jin WenYi
Youn Ui-Joung
Kim Hong-Jin
Lee Ik-Soo
Zhang XinFeng
Song Kyung-Sik
Seong Yeon-Hee
Bae Ki-Hwan
|
|
|
Abstract
|
|
|
|
Cytotoxic bioassay-guided fractionation of methanol extract of Angelicae Sinensis Radix led to the isolation of a new dimeric Z-ligustilide, named neodiligustilide (1), together with three known compounds, Z-ligustilide (2), 11(S),16(R)-dihydroxy-octadeca-9Z,17-dien-12,14-diyn-1-yl acetate (3), and 3(R),8(S)-falcarindiol (4). Among them, 2 showed the strongest cytotoxicity against L1210 and K562 cell lines with IC50 values of 2.27 ± 0.10 and 4.78 ± 0.18 μM, respectively, while 1 showed moderate cytotoxicity with IC50 values of 5.45 ± 0.19 and 9.87 ± 0.14 μM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 ± 0.90 and 2.87 ± 0.49 μM, respectively.
|
|
|
KEYWORD
|
|
|
Angelicae Sinensis Radix, Neodiligustilide, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|